Question

Does the leading strand require DNA ligase?

Answer 1

No!

Explanation:

The purpose of `"DNA ligase"` is to join the okazaki fragments that are manufactured at lagging strand of replication fork. While at leading strand, the nucleotides are added continuously to the growing `3^'` end. So it doesn't have any okazaki fragments, hence it doesn't need `"DNA ligase"` .

![https://yourmomislike.wordpress.com/2012/12/01/your-mom-is-like-an-okazaki-fragment/]()

Hope it helps!