Just as Avogadro's number of hydrogen atoms, 1H, has a mass of 1⋅g. Avocado's number of 16O, has a mass of 16⋅g. And Avocado's number of 18O, has a mass of 18⋅g.
We use Avogadro's number as we would any other collective number, a dozen, a gross, etc. Of course Avogadro's number, 6.022×1023⋅mol−1 is absurdly large.