Any chance second-semester/year Organic Chemistry topic categories can be added? e.g. Grignard Reactions, Benzene Sub/Elim Rxns, Robinson Annulation, etc.?

1 Answer
Truong-Son N.
Jan 4, 2016

To be more specific, here is a (comprehensive) list that I've compiled when sifting through Organic Chemistry by Paula Yurkanis Bruice:

Reactions of Aromatic Compounds

  • Electrophilic Aromatic Substitution / EAS (Benzene)

    • Halogenation
    • Nitration
    • Sulfonation
    • Friedel-Crafts acylation and alkylation

  • Monosubstituted Benzenes

    • Reactions involving Alkyl Substituents
    • Reactions involving Arenediazonium Salts
    • Activating and Deactivating Groups
    • Effects of Substituents as Directing Groups
    • Effects of Substituents on Reactivity towards EAS

  • Disubstituted Benzenes

    • Synthesizing Trisubstituted Benzenes
    • Nucleophilic Aromatic Substitution / NAS

  • Reactions of Non-Benzene Aromatic Compounds

    • Aromatic Five-Membered-Ring Heterocycles (EAS)
    • Aromatic Six-Membered-Ring Heterocycles (EAS, NAS)

Reactions of Carbonyl Compounds

  • Nucleophilic Addition-Elimination Reactions

    • The Tetrahedral Intermediate in Nucleophilic Addition-Elimination Reactions
    • Reactions of Acyl Halides and Acid Anhydrides
    • Reactions of Esters: Transesterification and Hydrolysis
    • Reactions of Carboxylic Acids
    • Reactions of Amides and Nitriles

  • Nucleophilic Addition Reactions

    • Reactions with Grignard Reagents (Aldehydes, Ketones, Esters, Acyl Chlorides)
    • Reactions with Hydride Donors (NaBH4, LiAlH4)
    • Reactions of Ketones and Aldehydes to form Imines and Enamines
    • Formation of Geminal-Diols, Acetals, and Ketals
    • Protecting Groups
    • Nucleophilic Addition to α,β-Unsaturated Aldehydes & Ketones

  • Enolate & Multi-Carbonyl Reactions

    • Acid/Base-Catalyzed α-Halogenation (Carboxylic Acids)
    • Acid/Base-Catalyzed α-Alkylation (Carbonyl Compounds)
    • The Michael Reaction: β-Alkylation of α,β-Unsaturated Aldehydes & Ketones
    • The Aldol Addition: Formation of β-hydroxyaldehydes / ketones
    • Dehydration of Aldol Addition Products
    • The Claisen Condensation: Reactions of Esters to form β-keto esters
    • Intramolecular Condensations and Additions
    • The Robinson Annulation: A Michael Reaction With An Intramolecular Aldol Addition
    • Decarboxylation of β-keto acids in Acid / Base
Related questions
Impact of this question
1692 views around the world
You can reuse this answer
Creative Commons License