Calculate the work required to transfer 1 mol of K+ from the blood to muscle cells?
Potassium ions are moved across cell membranes by “ion pumps,” which
make it possible for the cell to expend energy needed to maintain different
concentrations of ions on either side of the membrane. In humans, the
concentration of potassium ions in the blood is 5.0x10-3 M, while the concentration
inside of muscle cells is 0.15M. Calculate the work required to transfer 1 mol of
K+ from the blood to muscle cells.
Potassium ions are moved across cell membranes by “ion pumps,” which
make it possible for the cell to expend energy needed to maintain different
concentrations of ions on either side of the membrane. In humans, the
concentration of potassium ions in the blood is 5.0x10-3 M, while the concentration
inside of muscle cells is 0.15M. Calculate the work required to transfer 1 mol of
K+ from the blood to muscle cells.
1 Answer
The work required is 0.09 kJ.
Explanation:
A typical formula for the energy of ion transfer is
#color(blue)(bar(ul(|color(white)(a/a) ΔG = RTln(["K"^(+)]_text(in)/["K"^(+)]_text(out)) + ZFΔψ color(white)(a/a)|)))#
where
The first term in the expression represents the energy involved in crossing the concentration gradient.
The second term represents the energy involved in crossing the electrical gradient (the membrane potential).
In a typical skeletal muscle cell, the membrane potential for
The negative sign indicates that the inside of the cell is negative with respect to the surrounding extracellular fluid.
In this problem,
The transfer of 1 mol of potassium ions will require 0.09 kJ.
Under the specified conditions, the transfer of potassium ions to the muscle is almost energetically neutral.