How will you prepare propanamine from methyl chloride using suitable reactions?

1 Answer
Mar 24, 2016

How about the sequence below?

Explanation:

1. Convert to a Grignard reagent

"CH"_3"Br" stackrelcolor(blue)("dry ether"color(white)(m))(→) "CH"_3"MgBr"

2. React with ethylene oxide

"CH"_3"MgBr" stackrelcolor(blue)("1. ethylene oxide"color(white)(m))(stackrelcolor(blue)("2. H"^+color(white)(mmmmmml))(→)) "CH"_3"CH"_2"CH"_2"OH"

3. Convert to the chloride

"CH"_3"CH"_2"CH"_2"OH" stackrelcolor(blue)("PCl"_3color(white)(m))→ "CH"_3"CH"_2"CH"_2"Cl"

4. React with "NH"_3

"CH"_3"CH"_2"CH"_2"Cl" stackrelcolor(blue)("NH"_3color(white)(m))(→) "CH"_3"CH"_2"CH"_2"NH"_2