How will you prepare propanamine from methyl chloride using suitable reactions?

Question

2310 views around the world

You can reuse this answer
Creative Commons License

Answer 1 · 2016-03-24T23:36:48

How about the sequence below?

1. Convert to a Grignard reagent

$"CH"_3"Br" stackrelcolor(blue)("dry ether"color(white)(m))(→) "CH"_3"MgBr"$

2. React with ethylene oxide

$"CH"_3"MgBr" stackrelcolor(blue)("1. ethylene oxide"color(white)(m))(stackrelcolor(blue)("2. H"^+color(white)(mmmmmml))(→)) "CH"_3"CH"_2"CH"_2"OH"$

3. Convert to the chloride

$"CH"_3"CH"_2"CH"_2"OH" stackrelcolor(blue)("PCl"_3color(white)(m))→ "CH"_3"CH"_2"CH"_2"Cl"$

4. React with $"NH"_3$

$"CH"_3"CH"_2"CH"_2"Cl" stackrelcolor(blue)("NH"_3color(white)(m))(→) "CH"_3"CH"_2"CH"_2"NH"_2$