As we are seeking slope at (1,4), this point lies on the curve given by x^3y^2-(x+y)/(x-y)^2=C.
Putting values from (1,4), we get 1^3*4^2-(1+4)/(1-4)^2=C
or C=16-5/9=139/9 and function is x^3y^2-(x+y)/(x-y)^2=139/9
Now differentiating the imlicit function x^3y^2-(x+y)/(x-y)^2=C
3x^2y^2+2x^3y(dy)/(dx)-(1+(dy)/(dx))/(x-y)^2-(2(x+y))/(x-y)^3(1-(dy)/(dx))=0
or 3x^2y^2(x-y)^3+2x^3y(x-y)^3(dy)/(dx)-(x-y)(1+(dy)/(dx))-2(x+y)(1-(dy)/(dx))=0
or [2x^3y(x-y)^3-(x-y)+2(x+y)] (dy)/(dx)=[-3x^2y^2(x-y)^3+x-y+2(x+y)]
or (dy)/(dx)=[-3x^2y^2(x-y)^3+x-y+2(x+y)]/[2x^3y(x-y)^3-(x-y)+2(x+y)]
= [-3x^2y^2(x-y)^3+3x+y]/[2x^3y(x-y)^3+x+3y]
and at (1,4), slope is [-3*1^2*4^2(1-4)^3+3+4]/[2*1^3*4(1-4)^3+1+3*4]
= (48*27+7)/(-8*27+13)
= -1303/203
The tangent at (1,4) looks liike:
graph{(x^3y^2-(x+y)/(x-y)^2-139/9)(203y-812+1303x-1303)=0 [-10.87, 9.13, -4.08, 5.92]}