Question #d800d
1 Answer
A Lineweaver-Burk plot can distinguish among competitive, non-competitive, and uncompetitive enzyme inhibition.
Competitive Inhibition
A competitive inhibitor has a similar shape to the substrate. It binds reversibly at the active site, where it competes with substrate for binding.
But
Non-competitive inhibition
The shape of a non-competitive inhibitor is different from that of the substrate.
It binds to another site on the enzyme or enzyme-substrate and prevents the formation of products.
It causes a decrease in
Uncompetitive inhibition
The shape of an uncompetitive inhibitor is different from that of the substrate.
It cannot bind to the active site. It can bind to the enzyme-substrate complex only after it has been formed.
This reduces both
The lines end up parallel to each other.