There are a total of 10 letters.
If they were all distinguishable then the number of distinct arrangements would be 10!. We can make them distinguishable by adding subscripts:
BO1O2K1K2E1E2PE3R
If we remove the subscripts from the letter O's, then it no longer makes any difference what order the O's are in and we find that 12!=12 of our 10! arrangements are identical to the other half.
So there are 10!2! possible arrangements of the letters:
BOOK1K2E1E2PE3R
If we remove the subscripts from the letter K's a similar thing happens and we are left with half again. So there are 10!2!2! possible arrangements of the letters:
BOOKKE1E2PE3R
Finally, since E1, E2 and E3 can be arranged in 3! possible orders, then when we remove the subscripts from the E's there are 10!2!2!3! distinct arrangements of the letters:
BOOKKEEPER
10!2!2!3!=10!2⋅2⋅6=10!4!=10⋅9⋅8⋅7⋅6⋅5=151200