The line passing from x=4 and tangent to e^sqrt(x) has as slope
d/dxe^sqrt(x) evaluated when x=4. The derivative can be calculated with the chain's rule
d/dxe^sqrt(x)=e^sqrt(x)*d/dxsqrt(x)=e^sqrt(x)/(2sqrt(x)).
The slope is
m=e^sqrt(4)/(2sqrt(4))=e^2/4.
So the tangent has equation
y=e^2/4x+q
The q can be found imposing the passage of the line from the point (4, e^sqrt(4))=(4, e^2)
e^2=e^2/4*4+q then q=0 and the equation of the tangent is
y=e^2/4x
The orthogonal has the negative inverse slope, so the equation is
y=-4/e^2x+q
Again, to find q we have to impose the passage from (4, e^2)
e^2=-4/e^2*4+q
q=e^2+16/e^2=(e^4+16)/e^2\approx9.55 and finally the equation of the orthogonal is
y=-4/e^2x+9.55 or
y=-0.54x+9.55.